Hyperthermal Lipiodol Embolization And Thermocoagulation For The Treatment Of Primary Hepatocellular Carcinoma

Primary carcinoma of liver is one of the most grievous malignancies in the world. China is one of the places with higher incidence of a disease, and continuously increases in recent years. Currently in our country, the first place of mortality of malignancy in countryside is primary carcinoma of liver, and in the urban that is the second place after lung cancer. So it is very significant to improve the treat level of primary carcinoma of liver. Due to the liver has very strong compensation function, the patients hardly have clinic symptom at the forepart of primary carcinoma of liver. The discoveries of nonage liver cancer most are through physical check-up, if the patients go to see the doctor with symptom, then that will be the metaphase or the advanced stage. These patients loose their opportunities of resection operation by bad function of liver, bifoliate focus, over large of focus, the important blood vessel near focus or outside liver divertion. Since 20th century 50's, there appears transcatheter arterial infusion (TAI), which comes from the hepatic arterial radiography. In 1976, Goldstein first reported transcatheter arterial embolization (TAE). In 1983, professor Lin Gui in Shanghi Medical University first reported the result of clinic use of TAE. After that, TAI and TAE became more and more wide use in China, and the transcatheter hepatic artery chemoembolization (TACE) became the preferred treatment except resection operation. But after these years' expansion of TACE, its curative effect still need to be improved. The precursors and fellows around the world are working unremittingly from different angles to improve the effect of primary carcinoma of liver treatment.The liver cancer patients' body immunity obviously decline, so the biology treatment has been brought forward in 20th century 80's. Recently the immunitytherapy has been taken as the assistant of TACE widely, and obtains good effect.Within the big cancer, the middle part does not participate in growth, and the blood comes from artery, so it easily lacks of blood and putrescence. But the periphery of interface is active in growing, and requires more nourish, so the blood sometimes comes from both of the hepatic artery and portal vein. The portal vein provide more blood towards the small cancer, Ackeman demonstrated through experiment that 38.4% of the tiny cancers which smaller than 7mm are double blood supply, 42.3% are the hepatic artery supply and only 19.3% are portal vein supply. At the same time, the end of portal vein and the hepatic artery has distributaries and inosculations, and these are very important for the growth of the cancer. The experiment on animal shows that once the blood supply artery of the cancer embolized, the portal vein supply increase evidently. So there is more attention towards the portal vein embolism chemotherapy for the liver cancer intervention treatment.The most influential one is Norio's first report of unite embolism chemotherapy of the hepatic artery and portal vein in 1986. Its objective is interdicting both blood supply passage towards focus. It has very important significance for the recrudescence and transfer of vestige of cancer. Theoretically speaking, the unite embolism chemotherapy of the hepatic artery and portal vein is a effective treatment, but it is very complex and with high difficulty to carry through this treatment. So far, there is non of the simple technology of portal vein puncture embolism set up in medical field, so Norio's unite embolism chemotherapy of the hepatic artery and portal vein cannot be widely used.Base on the thermatology theory of tumour, the cell of tumour can be necrotic with temperature higher than 43C and last for 30 minutes. Platinic medicine for chemotherapy are the most detail studied for tumour thermatology and the most commen medicine for hyperthermal chemotherapy. CDDP buildup its medical effect with the increasing of temperature, it belongs to the non-threshold medicine (The medicine increase its antipersonnel with the temperature raising when the...