A Study Of The Expression Of Mucin1(MUC1) Gene In Malignant Hematological Diseases And Its Clinical Significance

[Objective]To detect MUC1 expression in the cases of hematoiogical malignant diseases and its clinical significance in these diseases, especially its targeting immunotherapeutic potency in these diseases. [Methods] The expression of MUC1 in the bone marrow, lymph nodes, and other tissues was assayed by immunocytochemical and immunohistochemical SP methods in total 77 cases of hematoiogical malignant diseases. The association between the expression of MUC1 and some clinic parameters was also analysised.[Results]The expression of MUC1 in AML and B cell malignant lymphoproliferative diseases especially in MM was significantly higher than that in normal blood cells (P<0.05). An analysis of correlation between the expression of MUC1 and other clinic parameters showed that increased MUC1 antigen expression was associated with some poor prognostic factors such as extramedullary infiltration and the age of older than 60-year-old patients with AML.[Conclusion] Our study showed that MUC1 was overexpressed in non-glycosylated form in AML and B cell malignant lymphoproliferativediseases, particularly in MM, and was associated with extramedullary infiltration as well as the age of older than 60-year-old patient with AML. MUC1 may be used as a poor prognostic factor in some malignant diseases. More importantly, it could be used as a immunotherapeutic methods for these diseases.