| Objective: To study the patterns of the expression of pituitary tumor transforming gene(PTTG) and basic fibroblast growth factor (b-FGF) gene in acute leukemia(AL) and multiple myeloma(MM) and to investigate the function of PTTG and b-FGF in tumorogenesis, in tumor invasion and metastasis, as well as the relationship of their expression with prognosis in AL and MM.Methods: Expression of PTTG and b-FGF were detected by means of immunocytochemistry in 53 cases of AL, in 46 cases of MM and 15 cases nomal marrow tissue as controls. The results were analysised statistically.Results: the expression of PTTG and b-FGF in AL group was higher than the control group significantly (P<0.01). In AL group, after chemotherapy, the expression of incipient group is higher than complete remission group significantly (P<0.01). The correlation of PTTG and b-FGF is positive (r=0.61, P<0.01); the expression of PTTG and b-FGF in MM group were higher than the control group significantly (P<0.01), the positive expression rates of PTTG and b-FGF in MM group and control group were 63.0% and 6.67%(P<0.05), 67.4% and 13.3%(P<0.05), respectively. The expression of PTTG and b-FGF were closely related to Durie-Salmon stage(P<0.05).Conclusions: Up-regulation of PTTG and b-FGF expression maybe involved in the progression of MM and AL, correlated closely with therapeutic effect. Associated detection of PTTG and b-FGF may help to judge the malignant degree and prognosis of AL and MM.
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