| Purpose: Diabetes mellitus (DM) is a sort of vascular disease affect general body. Diabetic Retinopathy (DR) was studied by many researchers, but the choroids were also influenced. This study was designed to investigate Diabetic choroidopathy and the relationship of diabetic choroidopathy with DR, in order to provide valuable theories for preventing and treating DR and make compensation for the ocular disease of DM.Method1 All subjects (DMs and controls ) were examined by physicists and oculists, some are excluded for their general disease and other ocular disease.2 According to the "the deviation standard of DR" and the results of FFA , Diabetes patients were divided into no diabetic retinopathy (NDR), nonproliferative diabetic retinopathy (NPDR), proliferative diabetic retinopathy (PDR).3 All subjects were examined by fundus fluorecein angiography(FFA), indocyaine green angiography(ICGA) technique at the same time ,observe two type of angiography results and analysis the images of patients in 3 groups ,in order to evaluate the diabetic choroidapathy. 4 Color doppler flow imaging (CDFI) was use to quantitate peak systolic velocity (PSV), end diastolic velocity (EDV) and resistence index (RI) of the ophthalmic artery (OA), the temporal posterior ciliary artery (PCA1), and nasal posterior ciliary artery (PCA2), in the control group and DM patients; using statistic software to analysis the hemodynamic parameters.5 Combining the ICG images and hemodynamic parameters to investigate the progression of piapetic choroidapathy.Results1 The CRA filling time of NDR,NPDR,PDR were 13.66±2.63s,13.58±2.75s,14.05±1.91s and there were no significant difference between DR and control group. The choroid filling time of NDR,NPDR,PDR were 14.10±2.70s,14.78±3.39s,15.38±1.82s and there were significant increase in 3 group compared to the control group.2 Choroid filling time of 54% NDR eyes were longer than the CRA filling time, 23% eyes' choroid filling time were similar to the CRA filling time, and the other 23% eyes' choroid filling time were shorter than the CRA filling time. Choroid filling time of 74% NDR eyes were longer than the CRA filling time, 21% eyes'choroid filling time were similar to the CRA filling time, and the other 5% eyes' choroid filling time were shorter than the CRA filling time. Choroid filling time of 85% NDR eyes were longer than the CRA filling time, 2% eyes' choroid filling time were similar to the CRA filling time.3 Lobular delayed choroidal perfusion were observed in 85% NDR eyes at early angiographic sign, and the lobular perfusion were disappeared at 22.80±3.84s; 54% eyes had the appearance of lobular spotty hyperfluorescent and hypofluorescent areas("salt and pepper" appearance) in late phase. Lobular delayed choroidal perfusion were observed in 95% NPDR eyes at early angiographic sign, and the lobular perfusion were disappeared at 31.74±4.80s; 54% eyes had the appearance of lobular spotty hyperfluorescent and hypofluorescent areas("salt and pepper" appearance) in late phase. Lobular delayed choroidal perfusion were observed in all the PDR eyes at early angiographic sign, and the lobular perfusion were disappeared at 22.80±3.84s; 92% eyes had the appearance of lobular spotty hyperfluorescent and hypofluorescent areas("salt and pepper" appearance) in late phase.4 OA: There was a significant decrease of EDV (6.91±2.20cm/s) in the NDR group compared to the control group(EDV:9.18±3.62cm/s)(p<0.05),but there was no significant decrease in PSV(27.96±6.34cm/s) in the NDR group compared to the control group (PSV:31.12±8.28cm/s). (p=0.11).There was a significant decrease in both PSV (25.62±6.85cm/s) and EDV (6.73±2.81cm/s) in the NPDR group compared to the control group (PSV:31.12±8.28cm/s, EDV:9.18±3.62cm/s) (P<0.05),and there was no significant decease in NPDR group compared to NDR group. There was a significant decrease in both PSV(21.96±5.71cm/s) and EDV(5.09±2.80cm/s) in the PDR group compared to the control group, NDR group,...
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