Clinical Observasion On The Effect Of Acupuncture Combined With Herb For Postmenopausal Osteoporosis

Purpose: To investigate the effect of acupuncture combined with processing herb for the reproductive endocrine of postmenopausal osteoporosis and bone metabolism levels, and research the functional mechanism of the effect from the angle of hypothalamic- pituitary- ovarian axis, suprarenal axis and thyroid axis.Method:30 cases of postmenopausal women (at the aged of 50 ~70 years) were selected with certain diagnostic standard. Choose the acupoints: "G4" area ( Antitragus-double), Sanyinjiao (SP6 -double) and Shenshu( BL23-double), Mingmen(DU4)were the main points, modified according to syndrome differentiation. Take 1 Herba epimedii( yin yang hud) capsules three times a day (Total raw herb 4. 8g/d) ;Puncture the points of SP6 and BL23 with filliform needles one time every three days; "G4" areas where were pressed by Auricular seed pressing and stimulate 3 times each day, one to two minutes each time. Two months make up an observing therapeutic course, measure each index before and after treatment respectively. The indexes are as follows: (l)The effect of acupuncture combined with herb on peripheral serum estradiol (E2), calcitonin(CT), osteocalcin(BGP), parathyroid hormone(PTH), testosterone(T), follicle stimulating hormone(FSH) , luteinizing hormone (LH), The serum E2, CT, BGP, PTH , T , FSH and LH levels were estimated by radioimmunoassay(RIA) with the blood of elbow vein. (2) Adopt the improved method of Kupper grade point, to estimate symptom. (3) Investigate the quality of life with MOS SF-36 (Medical Outcomes Study 36-Item Short-Form Health Survey) in before and after treatmentResult: (1) After treatment skeletal density was higher than those beforetreatment, There were significant difference before and after treatment ( P<0. 05). (2)After treatment the levels FSH and E2 were higher than those before treatment ( P<0. 05) ; There were no significant difference before and after treatment to the levels LH and T( P>0. 05). (3) The levels of hormone of calcium CT and PTH increase significantly after treatment( P<0. 05), BGP increase significantly after treatment ( P<0. 05), too. (4) There was obvious improvement to symptom after treatment, Kupper index number was increased (P<0. 05). (5) There were significant improvement after treatment in 8 fields of the quality of life (P<0. 05): Bodily pain(BP), General health(GH), Vitality(VT), Physical function(PF), Social function(SF), Mental Health(MH), among them, Physical function(PF), Bodily pain( BP), Health(MH) changes showed significant difference (P<0.001), while there were no significant variety to Role physical (RP) and Role emotion (RE) (P>0. 05).Conclusion: (1) The result showed that acupuncture combined with herb had the function in regulating the hypothalamic- pituitary- ovarian axis, suprarenal axis, thyroid axis and could improve the endocrine environment of women , increase E2, BGP , CT and PTH contain. (2)It could improve obviously the clinical symptom of patients of postmenopausal osteoporosis, mind and body health, enhance the postmenopausal women' s quality of life(QOL), positively prevent and cure the postmenopausal osteoporosis. (3) The effect of acupuncture combined with herb to postmenopausal osteoporosis is related to modulate the function of hypothalamic-pituitary-ovarian axis and adrenal cortex and thyroid.