Studies On Chemical Constituents Of Schisandra Chinensis Baill

This dissertation is composed of two chapters. The first chapter elaborates the studies on the chemical constituents of Schisandra chinensis Baill., as a result, thirty seven compounds were isolated from the 95% ethanol extract of S. chinensis, and twenty seven of them were identified on the basis of spectral evidences as well as X-ray crystallographic analysis, including Kadsurarin (1), Wuweizisu A (2), Gomisin G (3), Gomisin D (4), Gomisin J (5), y-schizandrin (6), Wuweizisu C (7), Meso-dihydro-guaiarestic acid (8), Ganwuweizic acid (9), Nigranoic acid (10), Kadsuric acid (11), Chamigremc acid (12), Chamigrenal (13); N-phenyl-2-naphthylamine (14), Sitosterol (15), Tetracosanoic acid (16), myristic acid (17), Monoethyl fumarate (18), Citric acid trimethyl ester (19), 2-hydroxy-propanetricarboxylic acid-2-ethyl ester (20), Citric acid (21), 2-hydroxy-propanetricarboxylic acid-1-ethyl ester (22), 2-hydroxy-propanetricarboxylic acid-2, 3- dimethyl ester-1-ethyl ester (23), 2-hydroxy-propanetricarboxylic acid-1, 3-dimethyl ester-2-ethyl ester (24) 3-hydroxy-4-methoxy-benzoic acid-methyl ester (25) 3, 4-dimethoxy-benzoic acid-methyl ester (26), protocatechnic aldhyde (27). Among them, for the first time, compound 14 was isolated in Schisandraceae family, Compound 1, 10 and 11 in Schisandra genus, and compound 16, 18, 20, 21, 22 in S. chinensis.Moreover, as a result of structure modification of compound 1, three new compounds were obtained including 5, 6, 7, 8-tetrahydro-1, 2, 13-trimethoxy-3-allyloxy- 6, 7- dimethyl- benzo [3, 4] cycloocta [1, 2-fj [1, 3] benzodioxole (38); 5, 6, 7, 8-tetrahydro-1, 2, 13-trimethoxy -3-(4-Bromo-benzyloxy)- 6, 7- dimethyl- benzo[3, 4] cycloocta [1, 2-f] [1, 3] benzodioxole (39); 5, 6, 7, 8-tetrahydro-1, 2, 13-trimethoxy- 3-benzyloxy-6, 7- dimethyl- benzo [3, 4] cycloocta [1, 2-f] [1,3] benzodioxole (40).The second chapter presented a review on the main chemical constituents Schisandra genus and their biological activities, as well as spectroscopic characteristics of dibenzocyclooctadiene lignans.