Biomechanical Study Of Bioactive Cervical Fusion Cage (BCFC)

ObjectiveIn our recent study, we have already syntheses HA granules of high purity and crystallinity with osteoinductive characteristics, and poly-L-lactide (PLLA), alse biocompatible and bioresorbable, becoming an optimal osteoinductive composite . Adjusting the conditions for HA and PLLA synthesis, constituent composite can be obtained suitable for application to human organisms as implants of cervical spinal fusion cage. The purpose was to develop the use of BCFC in clinic. In this article, In fresh six human cervical spine specimens, imitative surgical procedures were carried out and BCFC was inserted respectively in the intervertebral spaces. Pull-out tests of the implanted material (C4, 5) and three dimensional spinal stability evaluation (C5, 6) were performed. To evaluate the immediate effects and initial stability imparted to the human cadaveric spine by the newly designed and developed BCFC.Methods1.In six fresh human cervical spine specimens, resection of the C5,6 intervertebral discs were done and iliac crest bone ,BCFC,plate on BCFC were inserted respectively in the intervertebral space. Segemental three dimensional spinal stability (C5 , 6) wereevaluated .2.In six fresh human cervical spine specimens, resection of the C4,5 intervertebral discs were done and BCFC, iliac crest bone were inserted respectively in the intervertebral space. Segemental pull-out tests of the implanted material (C4,5) were performed.Results1.After discectomy, spines receiving the plate on BCFC exhibited an decrease in angular motion in all directions and a significant increase in stability in all directions(p<0.005).2.In extension, both BCFC and iliac crest bone were associated with a decrease in stability than the intact spine, but it was not significantly.3.In left and right axial rotation, BCFC exhibited an decrease in angular motion than iliac crest bone and a significant increase in stability (p<0.005); but it was not significantly than the intact spine.4.In flexion and left/right axial rotation, BCFC exhibited an decrease in angular motion than iliac crest bone and intact, and a significant increase in stability (p<0.005).ConclusionBioactive Cervical Fusion Cage is biodegradable, biocompatible material. BCFC could provide enough support, anti-slide ability and could remain or increase the height of intervertebral spaces. It completely meets clinical and biomechanical requirements. It is worth further medical researchand surgical application in spinal surgery.