Pharmacological Effect Of Alkaline Soluble Polysaccharide Extract Of Candida Albicans On The Leukocytopoiesis-promoting In The Leukopenia Mice

The present study was done to elucidate the pharmacological effect of the alkaline soluble polysaccharide extract of Candida Albicans on the leukocytopoiesis-promoting in the leukopenia mice. Mature male ICR mice were divided into following five groups: untreated control group, negative control group, positive control group A (G-CSF group), positive control group B (CAP group) and alkaline soluble polysaccharide of Candida Albicans group. Mice of four groups except the untreated control group were administered cyclophosphamide (100 mg/kg. d-1for three days) intraperitoneal to develop leucopenia. In the positive control group A (G-CSF group), every mouse was administered G-CSF (30μg/ kg d-1 for six days) intravenously ; in the positive control group B (CAP group), every mouse was administered CAP (1 rag/kg-cT1 for six days) intravenously; in the alkaline soluble polysaccharide of Candida Albicans group, every mouse was administered alkaline soluble polysaccharide of Candida Albicans (2 mg/kg'cT'for six days) intravenously. The peripherial leukocytes of all mice were counted before treated CTX, and 1, 3, 5,7 days after treated CTX..The conclusion is that the alkaline polysaccharide of Candida Albicans is a potent biological response modifier which has better effect than G-CSF and CAP; it has prosperous future for clinical generalizing.