Evaluate Serum TPSA,f/t Ratio And PSAD In The Differential Diagnosis Of BPH And Pca

Objective To evaluate serum tPSA ,f/t ratio and PSAD in the differential diagnosis of BPH and Pca. Methods Age,serum tPSA,fPSA and PV by B ultrasound in cases of 176 BPH and 56 cases of Pca were assessed and thus f/t ratio and PSAD were gained. Analyze the linear regression between age and PV,between age,PV and tPSA,t/f,PSAD in BPH and Pca.Evaluate tPSA,t/f,PSAD both in patients within and outside the "gray zone". Results ①In BPH ,PV is positively influenced by age and tPSA is positively influenced by PV too(b=0.198andβ=0.038;p<0.05both) but they are both negtive in Pca.②Both age and PV haven't linear regression to t/f (p>0.05 both) while PSAD is significantly to PV(p<0.05).③tPSA f/t and PSAD were significantly discriminated between benign and malignant diseases (p<0.001,p<0.01) when the assessed value were much higher beyond "gray zone"; When the assessed value were within the "gray zone", tPSA couldn't be a differential marker for the 2 conditions(p>0.05) whereas f/t and PSAD could(P<0.05 both). However , in the lower value range beyond the "gray zone" ,tPSA f/t PSAD couldn't specificly differential the two(p>0.05 both). Conclusions Serum tPSA is a prostae carcinoma marker, t/f and PSAD, being an adjuvant marker of tPSA ,play an importance role on the differential diagnosis in patients within the "gray zone".