The Study Of Immune Function And Risky Factors About Tic Disorders In Children

Objective:Tic disorders is a kind of neural and mental disease with evidenthereditary tendency. It has been found in some adolescents. Because we haveknown many factors can lead to tic disorders ,the study aimed at investigatingdeeply its　cellular immune function ,anti-ANA(antinuclear antibody),personality, mother＇ｓ　　pregnancy ,parental rearing patterns and familysurroundings ,exploring profoundly its etiology mechanism and providingappropriate measures of clinical intervention.Method:The paper adopted case control experimental method.The 30 childrenwith TD and 30 normal children were implemented laboratory check aboutantinuclear antibody(ANA),T lymphocyte subsets such as total T lymphocytepercent CD3,helper T cell percent CD4,suppressor T cell percent CD8 andhelp/suppressor radio(CD4/CD8)in blood and questionnaire about tic disordersfamily status,EPQ (children)and Egna Minnen av Barndoms Uppfostran(EMBU).The data was handled and analysed with SPSS11.0 and SAS8.0statistical soft system.Results: The CD3,CD4 and helper/suppressor ratio (CD4/CD8)weresignificantly lower in case group than in control group, the absorbency ofanti-ANA were significantly higher in case group than in control group.Family status questionnaire indicated that there were 9 factors which hadsignificant difference between the case group and the control group .The 9factors were heredity,parental marriage status,bad mood during the pregnancy,asphyxia of newborn,poisonous matter ,children＇ｓ　over-tension in mentalstate,catching a cold recently,inducing factors and the heavy study burden oneby one. EMBU showed: the factor"affect warmth"scores for the father andmother scale of EMBU in case group were significantly lower than those of IVcontrol group. The scores on factors such as "punishment" ,"refusal" ,"interference "of father and mother scale of EMBU in case group were foundsignificantly higher than those of the control group. EPQ showed:the scores ofP,N were significantly higher in case group than in control group. The scores ofL were significantly lower in case group than in control group. Single factorlogistic regression analysis indicated that the following factors EPQ-P,EPQ-L,ＥＰＱ－Ｎ,"punishment","refusal""interference ""affect warmth"of parents scale of EMBU and CD4 had significant difference. Logisticstepwise regression analysis indicated that"refusal"of father and mother scaleof EMBU were the most risky factors.　　Conclusion:Children with tic disorders had the abnormity of cellular immunefunction and the higher concentration of autoantibody being broughtout after the patients were affected by the virus and bacteria. Heredity,parental marriage status,bad mood during pregnancy,asphyxia of newborn,poisonous matter ,children＇over-tension in mental state,catching a coldrecently,inducing factors ,the heavy study burden ,the personality ofneurotic character ,psychic character and the parental bad rearing patternswould be the risky factors which resulted in tic disorders. Among thesefactors "refusal"of father and mother scale of EMBU were the most riskyfactors.