| Chronic hepatitis B, which is one of the clinical diseases that can't be treated easily, has been studied quite much. We have collected plenty of information about the objective research on typing according to syndrome differentiation and diagnostic index of traditional Chinese medicine. Typing according to syndrome differentiation of chronic hepatitis B must be related to some objective indexes. Pulse diagnosis, which occupies an important place in the field of syndrome differentiation, is one of the important diagnosis means of traditional Chinese medicine. Sphygmograph has been utilized to detect pulse parameters by modern traditional Chinese medicine that makes the pulsogram parameters objective and comparable. The author explored preliminarily the relationship between the clinical typing according to syndrome differentiation and the objective indexes by medical molecular biological technology, discovering that different types have not only different virus duplicated levels, but also special pulse parameters, which can be objective basis for different syndrome types.Virus duplicated level could be divided into three standards, which are higher than 105copies/ml, between 102copies/ml and 105copies/ml, and lower than 102copies/ml. In this experiment, all that were higher than 105copies/ml made up 53 percent of the total, between 102copies/ml and 105copies/ml is 27%, and the rest is 20%. Deficiency of liver and kidney yin type took 39.5 percent of the 81 examples detected. At the same time, liver depression and spleen asthenia type took 19.75% of the total, internal accumulation of damp-heat type took 16.05%, blood stasis obstructing collaterals type took 9.88%, and asthenia of splenorenal yang type took 14.81%. Statistical data indicated that in different types, the ratios taken by virus duplicated level were different, such as in liver depression and spleen asthenia type, the proportion was 68.75%, 18.75%, 12.5%; correspondently, it were 46.15%, 30.77%, 23.08% in internal accumulation of damp-heat syndrome, 50%, 37.5%, 12.5% in blood stasis obstructing collaterals syndrome, and 25%, 50%, 25% in asthenia of splenorenal yang type.The altitude of the main wave of liver depression and spleen asthenia type was the lowest among the five types. There was signal discrepancy (P<0. 05)between liver depression and spleen asthenia type asthenia of splenorenal yang type as well as between the former and blood stasis obstructing collaterals. There was no signal divergency (P<0. 05) in the angle of the main wave and the ratio of pulse according tosyndrome differentiation. Comparing the strong positive group with the positive group as well as the negative group, the angle of the main wave and the ratio of pulse had signal difference (P<0. 05),which was the same as comparing HBeAg with virus duplicated level. Signal difference wasn't be found (P>0. 05) when we multivariated typing according syndrome differentiation, pulse parameters and virus duplicated level, which was probably related with the content of the sample. It should be studied furthermore.As far as ALT and AST were concerned, there v/ere signal difference (P<0. 05), referred to typing according to syndrome differentiation and the duplicated level of HBV-DNA. AST of internal accumulation of damp-heat syndrome was much higher than that of asthenia of splenorenal yang syndrome (P<0. 05). As for ALT according to virus duplicated level, arranged from high to low, it was internal accumulation of damp-heat type, deficiency of liver and kidney yin type, blood stasis obstructing collaterals type, liver depression and spleen asthenia type, asthenia of liver and kidney yin type, and asthenia of splenorenal yang type. All ihat indicated that ALT and AST which expressed the level of damage to liver function had related to damp-heat. At the same time, the ratio of AST and ALT was signal divergence (P<0. 05)comparing the liver depression and spleen asthenia type with asthenia of liver and kidney yin type. The content of haemoglobin was also signal difference comparing a... |
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