The Therapeutical Effect Of Various Oxygen Therapy On Pulmonary Edema After Seawater Drowning In Rabbits

Objective To observe the therapeutical effect of hyperbaric oxygen(HBO) and mechanical ventilation on pulmonary edema after seawater drowning (PE-SWD) in rabbits. Methods Forty-nine New Zealand rabbits were randomly divided into the control group, the PE-SWD group ,the HBO therapy group and the mechanical ventilation group. The rabbits in latter two group were selected to receive HBO and mechanical ventilation therapy differently. Blood gas analysis , vital signs and lung injury status were monitored at various time points. After 3-hour therapy, 7 rabbits of each group were killed for pathology. The rest went on surviving and were observed till death. Results After HBO therapy and mechanical ventilation therapy in PE-SWD rabbits, cyanosis disappeared quickly, crackles were decreased, and PaO2 was significantly improved (P < 0.01). The abnormality of vital signs was ameliorated. The results of TNF- a after therapy were lower than the ones in PE-SWD group. It could be seen from the ratios of weight that mechanical ventilation relieved the degree of pulmonary edema better than HBO (P< 0.05) . In mechanical ventilation group and HBO group, the degree of lung injury was relieved and the rabbits had longer survival time than the ones in PE-SWD group (P < 0.01) . The ones in mechanical ventilation group had the longest survival time. Conclusions Our study showed that HBO therapy and mechanical ventilation significantly improved hypoxemia of PE-SWD in rabbits, and relieved the degree of lung injury to some extend. The rabbits in both HBO therapy group and mechanical ventilation group had longer survival time than the ones in PE-SWD group.