Mechanisms Of Pulmonary Edema After Seawater Drowning

Seawater drowning is very common in disaster, war, or tsunami caused by earthquake at sea. Pulmonary edema after seawater drowning (PE-SWD) is one of the main causes of death in seawater drowning. In order to study the mechanisms of PE-SWD, an appropriate working rat model with PE-SWD was established by injecting seawater 4 ml/kg intratracheally. The expressions of KGF and KGFR are increased. The pulmonary capillary permeability is extremly increased as well as W/D, PMN, MPO in lung parenchyma, and MDA both in lung parenchyma and plasma. TPL, DSPC, and the ratios DSPC/TPL in BALF decreased in 4 h. The de novo synthesis of PC increases in PE-SWD. Exogenous PS inhabits the de novo synthesis of PC in PE-SWD. Pouring seawater in rats with seawater drowning in 10 min increases the mortality. This efficacy should be verified in big animal model experiment.