| Objective: Acute progressive cerebral infarction(APCI) is gradually noted by people as an important ischemic cerebral stroke subtype. APCI refers to a kind of cerebral infarction that neurological function will deteriorate whether being treated or not after 6 hours after onset of cerebral infarction. Progression increases mortality and survivors have more permanent neurological deficits and functional disabilities. This prospective study was designed to determine the possible cause of cause of APCI and identify potential predictors and risk factors associated with APCI through 103 cerebral infarction in-patients. Patients were studied by analyzing the clinical ,biochemical,neuroimaging and brain electrical activity mapping(BEAM) in order to instruct clinical treatment and select efficiently therapy , and give some guidance to cerebral infarction to reduce the mortality and improve the patients'life qualities. Methods: To select 103 in-patients in department of neurology of our hospital from February 2004 to February 2005 including 32 APCI patients and 71 nonprogressive cerebral infarction patients to study. The examiners who were non-cerebral vessels disease to be selected as the control group in the same time. All patients were matched with diagnosis by clinical standards referred to the fourth national cerebrovascular diseases meeting in 1995. We evaluated general parameters (including sex ,age,temperature,blood pressure,NIHSS in admission,histories of other diseases),biochemical parameters (including blood glucose,lipoprotein,hemorheolegy),serum NSE,neuroimaging,BEAM between acute progressive cerebral infarction group and acute nonprogressive cerebral infarction group 。All patients on admission were examined by conventional CT/MRI. Patients without abnormality in the first examination were re-examinated after 48 hours. As for APCI patients, The CT/MRI examination was repeated on peak of neurological deterioration. Part of patients were examined by BEAM. It had 21 electrodes laying according to international 10/20 system. We traced EEG 5 minutes with the earlobes as reference eletrodes, and 30 seconds EEG without confusion was input computer to FTT exchange to obtain power of α,β,θ,δdistribution images and we analyzed δimages in this experiment. The univariate analyses were performed using SPSS for Windows version 11.5. Tests performed were the chi-square test for categorical variables and the t test for continuous variables. Results: 1 general parameters : univariate analysis showed , in 32 acute progressive cerebral infarction patients, having diabetes mellitus was 13 patients(40.63%),NIHSS in admission was 10.38±3.80; while in 71 aute nonprogressive cerebral infarction patients, having diabetes mellitus was 10 patients(14..08%), NIHSS in admission was 6.30±3.49. Therewere all significant differences between two groups(P<0.05). There were no significant differences in sex ,age,temperature,blood pressure,smoking,histories of hypertension and ischemic heart disease . 2 laboratory parameters: There were significant differences in hemorheoloy ,fibrinogen between acute progressive cerebral infarction and nonprogressive cerebral infarction, fibrinogen (4.67±1.16g/L) in progressive group was much higher than nonprogressive group. In lipoprotein, HDL(1.31±0.32mmol/L) and APOA(1.36±027g/l) in progressive group were lower than HDL(1.48±0.32mmol/L) and APOA(1.47±026g/l) in nonprogressive group, there were significant differences(P<0.05). Blood glucose in progressive group was 7.10±2.75mmol/L, which is higher than nonprogressive group(5.34±1.17mmol/L). There were significant differences (P < 0.05). Serum NSE (13.56±8.67umol/L) in progressive group was higher than Serum NSE(7.49±3.25umol/L) in nonprogressive group, there were significant differences(P<0.05), while Serum NSE was 2.845±1.332 uol/L in control group. 3 neuroimaging parameters: During 24 hours after cerebral infarction onset, positive rate(84.4%) of conventional CT in progressive group was higher than nonprogressive group...
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