Clinical Analysis On Risk Factors And Antiplatelet Therapy For Progressive Cerebral Infarction

Objective PCI(Progressive Cerebral Infarction) has high fatality rate and mutilation rate, and is one of refractory diseases in the Department of Neurology. It is urgent to stop the further development of CI(cerebral infarction). This study aims to explore the related risk factors of PCI, as well as the effect and safety analysis of oral administration of clopidogrel and aspirin to acute PCI.Method Toselect and retrospective analyze the clinical data of 144 patients with acute Lateral Cerebral Infarction from Department of Internal Medicine, the affiliated chaohu hospital, Medical University of Anhui, dating back to the period from September 2013 to September 2015.According to the National Institute of Health Stroke Scale(NIHSS) scores, will be Within 3 days after the attack by cerebral infarction, as long as HIHSS≥2 or more points, then the disease is seen as aggravated and can be diagnosed as PCI. Overall, there were a total of 62 cases of PCI and 82 cases of non progressive cerebral infarction. Then, it aimed to gather general clinical data of two groups and make clear the related risk factors of PCI for the purpose of guide treatment measures.At the same time, 62 patients with acute progressive cerebral infarction were randomly divided into treatment group(32 cases) and control group(30 cases), and the control group was treated with long-time aspirin(100 mg, 1 /d).By contract, treatment group were treated on the basis of the combination of oral clopidogrel(75 mg/d, 1 times /d). The total treatment was 30 days. After 30 days, the treatment group stopped clopidogrel and two groups continued long-term oral aspirin for secondary prevention. The NIHSS score and Barthel Index(BI) of Daily Living Scale were used to assess the status of neurological deficits and the rehabilitation of neurological deficits of patients before the treatment and 3, 7, 30, 90 days after the treatment, and observed the adverse drug reactions occurred in the two groups.Result(1)PCI and NPCI general data comparison, solecism antihypertensive, hypertension, intracranial artery stenosis, the temperature rose, and LDL(low density lipoprotein) rose, which are the independent risk factors of PCI(Progressive Cerebral Infarction).(2) Compared with the control group, the NIHSS score and Barthel Index showed statistically significant differences(P < 0.05), especially the 3d and 7d NIHSS core and Barthel Index;Combined oral aspirin and clopidogrel can more effectively improve acute progress cerebral infarction patientsmoderate neurologic deficits.(3)The adverse reactions of the two groups showed no statistical significance.Conclusion:The independent risk factors of PCI, includes solecism antihypertensive, hypertension, intracranial artery stenosis, the temperature rose, and LDL(low density lipoprotein) rose. The combination of aspirin and clopidogrel in the treatment of progressive cerebral infarction can effectively control the progression of the disease and promote the early recovery of neurological function, with good safety.