Expressions And Significance Of Survivin,PTEN Proteins In Human Lung Cancer

Objective To study the expression of Survivin and PTEN protein in human lung cancer and their relationships to the biological behavior of lung cancer.Methods An immunohistochemical method (PV-9000 Polymer Detection System For Immuno-Histological Staining) was used to detect the expressions of Survivin, PTEN proteins in 65 cases of lung cancer, 10 cases of adjacent tumor tissues and 8 cases of benign pulmonary disease tissues. SPSS 11.5 statistic software was applied to analyze the data.Results (1) The positive expression of Survivin protein was 70.77% (46/65) in lung cancer. It was negative in adjacent normal lung tissue samples and in benign pulmonary disease tissues. It was 78.85% (41/52) in non-small cell lung cancer (NSCLC), 38.46% (5/13) in small cell lung cancer (SCLC). There was a significant difference between in non-small cell lung cancer and in small cell lung cancer (P<0.01). 77.78% (21/27) in squamous cell carcinoma, 80% (20/25) in adenocarcinomas. There was no significant difference between in squamous cell carcinoma and in adenocarcinomas (P>0.05). The positive expression of PTEN protein was 49.23% (32/65) in lung cancer, It was 90.00% (9/10) in adjacent normal lung tissue samples and 100.00% (8/8) in benign pulmonary disease tissues. There was no significant difference between in adjacent normal lung tissue samples and in benign pulmonary disease tissues (P>0.05). It was 48.08% (25/52) in non-small cell lung cancer, 53.85% (7/13) in small cell lung cancer. There was no significant difference between in non-small cell lung cancer and in small cell lung cancer (P>0.05). It was 55.56% (15/27) in squamous cell carcinoma and 40% (10/25) in adenocarcinomas. There was no significant difference between in squamous cell carcinoma and in adenocarcinomas (P>0.05). The significant relationship was observed between in adjacent normal lung tissue samples and lung cancer (P<0.01), The significant relationship was observed between in benign pulmonary disease tissues and lung cancer too (P<0.05). There was no significant difference in the groups of clinical stage for Survivin expression. The positive expression of PTEN is associated with clinical...