Association Of Genetic Polymorphisms In The DNA Repair Gene XPA And Risk Of Lung Cancer

Objective: To study the relationship between polymorphisms in the DNA repair gene XPA and the susceptibility to lung cancer in a Chinese population. Methods: The XPA A23G genotypes were determined by the PCR-restriction fragment length polymorphism (PCR-RFLP) method in 310 histologically-confirmed lung cancer cases and 341 age and sex frequency-matched cancer-free controls. We also genotyped the G-1796A and RS3176689A/T polymorphisms in 202 lung cancer cases and 247 cancer-free controls by the Tagman assays. Results: The XPA A23G genotype frequencies were 27.1% (AA), 42.9% (AG), and 30.0% (GG) in the case patients and 21.1% (AA), 52.8% (AG), and 26.1% (GG) in the control subjects respectively, and the difference was statistically significant (X~2 = 6.61, P = 0.037). Multivariate logistic regression...