Expression Of Vascular Endothelial Growth Factor Transmembraneous Receptor 1 In Placenta Of Pregnancy-induced Hypertension

Pregnancy-induced hypertension (PIH) , a life-threatening complication of pregnancy, is characterized by the onset of high blood pressure and proteinuria. PIH occurs about 9.4% in China.The pathogenesis of PIH is thought to act at three levels: defective placentation, placental ischemia, and endothelial cell dysfunction. Of these, the placental ischemia is considered to be a first place factor associated with PIH. At a morphologic level, interstitial invasion often is shallow in PIH placenta. This defect is thought to lead to hypoperfusion of the placenta. At a molecular level, these defects are associated with particular deficits in the differentiation process where by cytotrophoblasts-epitheliar cells of ectodermal origin assume vascular-like properties.Vascular endothelial growth factor transmembraneous receptor 1 (VEGFR1) is a critical regulator for placenta and vascular growth and function. The study of its expression in PIH placenta will help us to understand the pathogenesis of PIH better.