Predictive Value Of S100 Protein Expression On Early Neurobehavioral Outcome In Children Whith Enteroviral Encephalitis

Objective To investigate the predictive value of S100B protein expression on earlyneurological behavior outcome in children with enteroviral encephalitis.Methods The viral isolation or/and polymerase chain reaction was used to detectenterovivuses in 44 children with viral encephalitis .The double-antibodies sandwich ELISA wasused to detect S100B protein concentrations in crebrospinal fluid(CSF) and sera in these 44patients and 20 healthy children.These patients were divided into 2 groups according to durationof altered concionsness.Results (1)Altered concionsness lasted 3 days and above in severe patients ,82.4% coma,Altered concionsness lasted within 3 days,37.0% coma.There was significantl difference in thesetwo groups(x~2=8.64, /?<0.01).82.4% of the severe patients presented neurobehavioralabnormalities,while 37.0% of the mild patients did,which showed significantly difference(t=8.33,p<0.01). (2)The concentrations of S100B protein in both sera and CSF in severe patients during acute stage were significantly higher than that in mild patients(t=4.37,P<0.01; t=4.38, p<0.01). (3)The concentrations of S100B protein in CSF during restoration stage after 15-day therapy in severe patients were still higher than that in mild patients and control children.but showed no significantly difference in sera..(4) The concentrations of S100B protein in sera at the acute stage in both severe and mild patients were significantly higher than that in the control group(t=7.38,p<0.01; t=5.75,p<0.01),and still higher in severe patients during the restoration stage . There were no significant difference of the concentrations of S100B protein in sera in mild patients of the restoration stage and the control group(f=1.32,p>0.05). (5) Linear correlation analysis indicated that the concentrations of S100B protein in sera and CSF in...