Study On The Relationship Between Plasma ADM,ET-1 Levels And Pulmonary Artery Systolic Pressure In Patients With Congenitsl Heart Disease

Objective Adrenomedullin(ADM)is a novel hypotensive peptide that was isolated from human phenochromocytoma. It was demonstrated that ADM levels were increased in patients with congestive heart failure, hypertension, and renal failure etc. But the relation between ADM and pulmonary hypertension (PH) associated with congenital heart disease(CHD) has not been fully understood. Therefore, the present study was to observe the changes of ADM, endothelin-1 (ET-1) levels in in patients with congenital heart disease to examine their efect on PH and to probe into their clinical significance.Methods Thirty patients with congenital heart disease were enrolled at random as study group. Randomly recruited control group included 20 healthy people. Plasma levels of ADM and ET-1 were determined by radio- immunoassay pre-operation and 24 hours and 4 weeks after operation respectively. Pulmonary artery systolic pressure (PASP) was measured by echocardiography at the same time.Results (1) Pre-operation: Plasma ADM and ET-1 levels were found significantly higher in study group than those in control group (p<0. 01). Plasma ADM and ET-1 levels in cases of congenital heart disease were positively correlated with pulmonary artery systolic pressure (p<0. 01). (2) 24 hours after operation: Plasma ADM and ET-1 levels were decreased than those in pre-operation in study group as well as pulmonary artery systolic pressure (p<0. 05). Thoes were still statistic differences in in study group and control group (p<0. 01). (3) 4 weeks after operation: Plasma ADM and ET-1 levels were decreased to normality in study group as well as pulmonary artery systolic pressure (p<0. 01), and there were no statistic differences in in...