The Study Of Correlation Between The Polymorphism Of GST Genes And Familial Susceptibility To Hepatocellular Carcinoma In The High Incidence Area Of Guangxi

Objective: To study the association between the GST genes polymorphism and the other relevant risk factors and the familial susceptibility to hepatocellular carcinoma (HCC).Methods: To the 88 cases from HCC high incidence families and 115 from control families, relevant risk factors of HCC were collected by the questionnaires in the high risk area of Guangxi, at the same time 10ml peripheral blood were collected ,then the infection rate of HBV in serum were tested and the polymorphisms of GSTM1 and GSTT1 in blood cell DNA were tested by multiple PCR too. Results:⑴Among the high risk family group and control group, 70.5 % (62 / 83) and 60.8 % (65 / 107) respectively have the GSTM1 null genotype , the difference is significant(x2=4.11,P=0.043) ,Odds Ratio(OR) is 1.908(95%C I= 1.017～3.578).⑵Among the high risk family group and control group, 62.8%(49 /78) and 57.3%(59/103)respectively have the GSTT1 null genotype , the difference is not significant(χ2=0.566,P=0.452),Odds Ratio(OR) is 1.260(95%C I= 0.690～2.302).⑶Among the high risk family group and control group, 30.68%(27/88)and 12.17%(14/115) respectively are HBsAg positive in serum, the difference is significant(χ2=10.595,P=0.001) ,Odds Ratio(OR) is 3.193 (95%CI=1.555～6.557).⑷After analysis by the non-condition logistic regression ,we found that GSTM1 null genotype,positive HBV infection in serum and corn intake is the major high risk factors of the familial susceptibility to HCC .Conclusion: The polymorphism...