Study Of Retrograde Coronary Sinus Perfusion In Beating Heart On Alleviation Of Inflammatory Response Induced By Cardiopulmonary Bypass

Objective:To evaluate the effect of retrograde coronary sinus perfusion in beating heart surgery in alleviating the systemic inflammatory induced by CPB on detecting tumor necrosis factor-α(TNF-α), interluekin-6(IL-6), interluekin-8 (IL-8), interluekin-10(IL-10), polymomhoneuclear(PMN) during surgery of retrograde coronary sinus perfusion in beating heart and operation on arrested heart with moderate hypothermia CPB and after. Methods: 20 patients with defect of mitral valve or defect of mitral valve and aortic valve attacked by rheum heart disease were divided into observation groups (retrograde coronary sinus perfusion in beating hear) and control groups(arrested heart with moderate hypothermia) randomly. Observation groups received surgery of retrograde coronary sinus perfusion in beating hear with mild hypothermia(32±℃),control groups received operation on arrested heart with moderate hypothermia(28～30℃) CPB. Blood samples were taken immediately after CPB(T1), 30min after CPB, 30min after aortic cross removing (ACR), 60min ACR, 120min ACR for detection TNF-α, IL-6, IL-8, IL-10 and PMN. Results: TNF-α, IL-6, IL-8 and IL-10 in both groups were increased and TNF-α, IL-6 , IL-8 in observation groups were lower than those in control group (P<0.05), but IL-10 in observation group was more high than it in control group(P<0.05). PMN in both groups were not different (P>0.05) 30 min after CPB. Conclusion: Retrograde coronary sinus perfusion in beating heart can alleviate systemic inflammatory response and decrease of cytokine.