Clinical Research Of Myocardial Protection Of Continuous Warm Blood Perfusion

Objective To evaluate the difference in myocardial protection of continuous potassic warm oxygenated blood perfusion compared with intermittent potassic cold oxygenated blood perfusion. Methods Twenty patients subjected to patch repair of ventricular septum defect were randomly assigned to continuous potassic warm oxygenated blood perfusion group (WBP group n=10) and intermittent potassic cold oxygenated blood perfusion group (CBP group n=10). Level of creatinekinase(CK), creatine kinase isoenzyme-MB(CK-MB) and potassium in serum were measured before CPB and 0, 6, 24hours after aortic cross-clamp removal; Myocardial ultrastructure, automatic resuscitation rate and use rate of positive inotropic agents were observed after aortic cross-clamp removal. Results The levels of serum CK and CK-MB at 0, 6 and 24 hours after aortic cross - clamp removal was significantly lower in WBP group than those in CBP group (P<0. 05). Atrial septum ultrastructure was slightly changed in WBP group , but that was more seriously damaged in CBP group. Automatic resuscitation rate and use rate of positive inotropic agents were better in WBP group than those in CBP group(P<0. 05). Conclusion Myocardial protection of continuous potassic warm oxygenated blood perfusion may have a remarkable result to prevent myocardial ischemia and reperfusion injury during operation of congenital heart disease, provide a quiet heart and clear operative field, and prolong the safe aortic cross-clamping time.