A Study For The Treatment Of Tumor By Electromagnetic Pulses Combined With Low Dosage Of Anti-Cancer Drugs

With the hydrophobic inner the phospholipid bilayer of cell membrane form the permeability barrier for the transportation of aqueous and greart molecules etc. While exposed to instantaneous electromagnetic pulses, transient reversible micropores appear on the membrane which suppreses the membrane's permeability barrier and provides pathways for the movement of ions, aqueous molecules and proteins etc, this is termed electroporation. Electrochemotherapy(ECT) based on the combinition use of electroporation and chemotherapy drugs to treat tumor could decline the permeability barricade and enhance the drugs' constraining effect on tumor.In this paper, KM mice carring S180 tumor and Nude mice carring human ovarian carcinoma were treated with ECT and the samples' dielectric constant were measured according to the perturbation theory, that provide foundations for the clinic applications of the ECT. The paper is divided into four parts. In the first part, the principles and the applications of electroporation were described. In the second part, the treatment of KM mice by different methods were studied and it proved that electroporation could enhance the anticancer drugs' destructive effect on tumor. In the third part, ECT is applied to treat the human ovarian carcinomas on nude mice. With the most optimal electric perameters been studied, the treatment proved that ECT could either suppress the rapid growth of the SKOV3 cells or the ovarian carcinomas based on the analysis of the SKOV3 cells growth curve, restraining rate etc. In the last part, permittivity of the samples were measured based on a developed perturbation method whose volume could be determined more precisely.