The Use Of Chiral Moleculary Imprinted Polymer And Solid-phase Extraction On Selected Ibuprofen

The side-effect or toxicosis caused by improper use of medicine makes it important to screen the drug clinically. Solid-phase extraction (SPE) is gradually substituting for the traditional liquid-liquid extraction (LLE) for its simplicity, low-in-price, less organic solvent, easily automation, etc. The ordinary SPE sorbents such as alkyl-silica, copolymers, graphitized carbon are not highly selective which hinders its development. The molecular imprinted technique is taken more and more care for its predetermination, selective recognition, widely use. Molecularly imprinted solid phase extraction is the most possibly commercialized technology at present application of molecular imprinted technique.We found that the cefathiamidine (CTX) imprinted polymer shows higher selectivity which use the basic 4- vinylpyridine (4-VP) as monomer comparing to the methacrylic acid (MAA), stronger affinity when the ratio between the template and the monomer is 1:6 rather than 1:4 or 1:8, faster rebinding which use toluene as porgen in place of acetonitrile.Molecularly imprinted polymers using Methyl dopa as template ,acrylamidc and MAA as functional monomers are prepared .UV(ultraviolet) studies showed that the template Methyl dopa and functional monomers acrylamidc former complexes. The polymer taking AM as functional monomer and 1:1 CH3OH-CH3CN as solvent obtained higher selectivity for Methyl dopa. Molecular imprinted Polymers will exhibit practical utility for enrichment and determination of trace Methyl dopa.We use chiral funcitonal monoer and R-buloprofen prepared chiral molecularly imprinted polymers, and the molecularly imprinted polymer was used as adsorbents of solid phase extraction. The result was good.Moreover, we have discussed the binding and rebinding mechanism by UV-vis spectrum, binding experiment, SPE procedure, etc.