The Effect Of Peritoneal Oxygenation On Treating Acute Lung Injury Combined With Cisapride

Objective: To explore the effect of peritoneal oxygenation combined withcisapride on treating acute lung injury.Methods: After acute lung injury was induced in adult rabbit with oleic acid,twenty-four rabbits were randomly divided into four groups(n=6,each) andreceived: peritoneal oxygenation without cisapride group(group A), non-peritonealoxygenation with cisapride group(group B) ,peritoneal oxygenation with cisapridegroup(group C) and non-peritoneal oxygenation without cisapride group(groupD). The changes of blood gas, heart rate(HR), mean artery pressure(MAP) wereobserved after acute lung injury was induced and treatment was commenced at1,2,4 hours.At the end of experiments,lung tissues from right lung were employedto detect the content of interleukin-6,the level of CC16mRNA expression and toobserve pathomorphologic changes.Results: PaO2 in group A and group C was obviously increased, but in groupB and group D was slightly increased. Extraordinarily, compared with group A,group B and group D , PaO2 was increased in group C is remarkable(P<0.05).PaCO2 was no significant difference between each other group in 4 hours aftertreatment. MAP were no obviously changed in group B and group D,meanwhilewere gradually increased in group A and group C(P<0.05).The content ofinterleukin-6 in group A and group C was lower than that of group B and groupD(P<0.05) and the content of interleukin-6 in group C was lower than that of groupA(P<0.05).Moreover,the expression of CC16mRNA in group A and group Cwas higher than the expression of CC16mRNA in group B and group D(P<0.05),inthe same way, the expression of CC16mRNA in group C was higher than theexpression of CC16mRNA in group A(P<0.05). Conclusion: Cisapride increases arterial oxygenation farther in rabbits withacute lung injury treated with peritoneal oxygenation , probably due to its ability toincrease splanchnic circulation. It should be considered as an adjuvant medicationto peritoneal oxygenation.The machnism treated with acute lung injury seemed toreduce the release of the proinflammatory cytokine interleukin-6 and to increasethe expression of CC16mRNA: a protectant factor in the epithelial cell of bronchi.