The Clinical Study Of Qian Cao Nao Mai Tong For The Treatment Of Acute Ischemic Stroke

Background and purpose: Evaluate the clinical curative effect and security of qian cao nao mai tong for the treatment of acute ischemic stroke objectively. Methods; This randomized, open , controlled trial included 200 patients with acute ischemic stroke which were randomly assigned to control group(100) and treatment group(100). hi control group, only the routine treatment were given and in treatment group, the routine treatment and qian cao nao mai tong were given orally at the same time. All patients were evaluated with Neurologic deficit score, Activities of daily living(ADL), Mini-mental state examination(MMSE) and Center of epidemiological survey depression scale(CES-D) before treatment, 2 weeks after treatment, as well as 4 weeks after treatment. Hemorhealogy of 80 patients were tested before treatment and 4 weeks after treatment. The side-effect of qian cao nao mai tong was observed. Result: In the trial, 180 cases were completed and 20 cases were missed. For 2 weeks' treatment, prominency of treatment group(46.7%) was higher than control group(36.7%) significantly (p<0.05) ,but the efficiency were no different between two groups. For 4 weeks' treatment, efficiency of treatment group(85.6%) was higher than control group(70.0%) significantly (p<0.05) and prominency of two groups were all higher than 2 weeks(58.9% and 57.8%).MMSE score of treatment group (27.65 + 6.62) increased significantly than control group (24.68±8.12) and CES-D score (11.70±4.13) decreased than control group (13.78±5.77) (p<0.05) after 4 weeks, In treatment group, rate of cognitive impairment(37.8%) and sentimental disorder(43.3%) were all less than control group. Rate of ADL impairment of patientsin treatment group(61.1%) was less than control group and before treatment and patients were more independence significantly after 4 weeks (p<0.05) . Through the observe to 80 patients, platelet aggregation rate, plasma viscosity and fibrinogen of patients in treatment group were lower significantly than control group, as well as than before treatment (p<0.05). No side-effects of qian cao nao mai tong were found. Conclusion: Qian cao nao mai tong for treatment of acute ischemic stroke can decrease patients' neurologic deficit score , improve cognitive function and ADL and relieve depression. It also can improve hemorhealogy. Qian cao nao mai tong is effective and secure for the treatment of acute ischemic stroke and it can be a adjuvant.