Clinical Significance Of COX-2 Expression In Human Breast Cancer

Objective To investigate the relationship between the expression of COX-2, c-erbB-2, P53 and the clinicopathologic characteristics in breast cancer , and discuss the role and clinical significance of COX-2 in the carcinogenesis and development of breast cancer. Methods 98 patients with breast disease were operated and divided into four groups: group of breast cancer, fibroadenoma, benign hyperplasia and normal breast . Sections were cut and immunostaining was performed using a COX-2-specific antihuman mouse monoclonal antibody. Results The positive rate of COX-2 was 60.4% in the group of breast cancer, 30% in the group of fibroadenoma , 15% in benign hyperplasia, and normal breast tissues expressed COX-2 negetively. COX-2 was over expressed in the breast carcinomas with more than 2cm large, lymph node metastasis, ER negative ,PR negative, c-erbB-2 positive and P53 positive ,but had no correlations with the age, TNM stage and the pathologic type. Conclusion COX-2 play an important role in the carcinogenesis , development and metastasis of breast carcinoma. As c-erbB-2 and P53 are the typical oncogene and antioncogene, the relationship between COX-2 over...