Influences Of Jejunal Nutrition On Pancreatic Excrine Secretion At Pancreatitis Rat And Its Neuromechanism

Changes of pancreatic exocrine secretion(PES) and its mechanism in acute pancreatitisis is uncertain now. There are a few nutrition treatment methods for acute pancreatitis. Whether these enteral nutrition schemes have an impact on PES and the mechanism of its modulation is not sure. We have successfully constructed experimental acute cutaneous and necrosis pancreatitis rat models, and measured the volume and protein level of PES in normal and pancreatitis rats. It shows that pancreatitis rat groups have a significant lower PES level than the normal group. Then we gave 0.3mol/L maltose or 3% NaCl as enteral nutrition to these two groups, and found the enteral nutrition did not increase the volume and protein level of PES. Meanwhile, we also used immunohistochemistry methods to analyze c-Fos, substance P(SP) receptor and Glu receptor at nucleus tractus solitarius(NTS), and found they expressed higher in enteral nutrition group than in contrast group. The result indicates that enteral nutrition can excite vagal afferent nerve fiber at pancreatitis models, and the excitation can be transmitted to medulla oblongata but do not induce changes of PES. It was inferred that the central integration mechanism, pathway of vagal efferent nerve or status of effetor may be different from normal during acute pancratitis. Further investigations are needed to bring details to light.