The Expression Of Prostasin In Prostate Carcinoma

Objective: To explore the biological function of prostasin in prostate carcinoma. Methods: RT-PCR analyses were used to examine the expression of prostasin in prostate cancer cell lines. Also RT-PCR and immunohistochemistry analyses were used to examine the expression of prostasin in prostate cancer tissue. Results: The expressions of Prostasin mRNA in BPH—1 and LNCaP are higher than those in DU-145 and PC-3. (p<0.01). The difference of the expressions of Prostasin mRNA between BPH — 1 and LNCaP are not statistically significant (p>0.05). Also the difference between DU-145 and PC-3 are not statistically significant (p>0.05). The expressions of Prostasin in normal human prostate tissue, benign prostate hyperplasia and a non-invasive human prostate cancer tissue are higher than those in invasive human prostate cancer tissue. (p<0.01). The difference of the expressions of Prostasin between normal human prostate tissue, benign prostate hyperplasia and a non-invasive human prostate cancer tissue are not statistically significant (p>0.05). Conclusions: Our data indicate that Prostasin may be suppressed prostate cancer invasion.