Inquisition And Clinical Characteristic Analysis On Occurrence Of Diabetes In Patients With Chronic Hcv

Many researches have discovered that the occurrence of diabetes is significantly higher in patients with chronic hepatitis C than in patients with other types liver disease since 1989 discovered hepatitis C virus, and many researches have discovered that HCV infection rate is also high in the diabetic. In order to confirm the relation between HCV infection and type 2 diabetes, we carried on this item. Methods: Select 134 patients with chronic hepatitis C and 237 patients with chronic B hospitalized in our hospital between 1999-2003 years ,which is divided into the chronic liver disease set and cirrhosis set in order to carry on checking against the analysis and compare them the occurrence of type 2 diabetes ;at the same time, related factor that statistics to have something to do with it take place. Select 140 type 2 diabetics and 203 common check-up crowds random at the same time, to examine their circumstance of HCV infection. Result: There are 13 patients suffering type 2 diabetes in 98 examples with chronic hepatitis C; and 8 patients in 145 examples with chronic hepatitis B suffering type 2 diabetes .In the cirrhosis sets, 36 patients with hepatitis C sufferer 14 the examples merge type 2 diabetes, 92 patients with hepatitis B sufferer 13 the examples merge 2 diabetes. In related factor, there are 96 examples in HCV infections whose age is over 40 years, merging type 2 diabetes are 26; Men and women's sex compares to 3.5:1; In 140 type 2 diabetics, 5 cases infected HCV ;In common check-up crowd, 0 case infected HCV. Discussion: Pass the analysis to the above-mentioned case, the result enunciation, regardless in the chronic hepatitis set, be still the cirrhosis set, the chronic HCV infections all compare the chronic HBV infection to alter to merge the diabetes, and the occurrence of diabetes of in cirrhosis set is obvious high in the chronic hepatitis set, confirmed the cirrhosis in diabetes be taken bad function. The foreign scholar think that Peripheral insulin-resistance and impairment of the hepatocellular function are two major possible causes of diabetes mellitus in liver cirrhosis. The beta-cell capacity, to compensate the insulin-resistant state to avoid the onset of frank diabetes mellitus plays a critical importance. Many factors may induce a reduction of the beta-cell function in patients with liver cirrhosis. It is likely that the high prevalence of diabetes in liver cirrhosis is due to the early onset of strong insulin-resistance coupled to a deficient beta-cell function aggravated by hepatic disease-related factors. The male is obvious on the sex high in female, and is closely related with age, with the obvious increment of the growth outbreak rate of the age. In univariate analysis, older age, hepatitis severity status sedentary work, body mass index of > or 25 kg/m2, and anti-HCV positivity were significantly associatedwith type 2 diabetes (p<0.05).Age in the occurrence of the diabetes is an importance, in multivariate logistic regression, anti-HCV positivity was strongly associated with type 2 diabetes in subjects aged 35-49 years (odds ratio (OR)=3.3, 95% confidence interval (CI): 1.4, 8.0). We can see from the above analysis, age and HCV infection were independent risk factors for diabetes. Can see, the HCV infection and age, sex, cirrhosis and the occurrence of the diabeteses closely related from the above analysis. At the same time the researches discovered the occurrence of type 2 diabetics in the HCV infections is obvious higher than in common crowd. Analysised 5 HCV infections, we discovered that 2 cases among them have the blood transfusion history, the occurrence of the diabetes is all after transfuse blood, hint infection of HCV may early in the diabetes of occurrence. Have the research enunciation: among those at high risk for diabetes, persons with HCV infection were more than 11 times as likely as those without HCV infection to develop diabetes (relative hazard, 11.58; 95% confidence interval, 1.39-96.6). In conclusion, pre-existing HCV infection may increase the risk for type 2 diabetes in persons with recognized diabetes risk factors. Why HCV infection cause the occurrence of diabetes? It concrete mechanism is still not explicit, possibility have something to do with following factor :the oneself immunity respond,duplicating of the HCV virus outside liver,the iron metabolismabnormality ,the liver steatosis ,insulin-resistant and the interferon treatment .Among them we can't neglect to the pancreas disorganization function. That is the research detection: Many HCV infections sufferer the pancreas surroundings appears the lymphoid knot swollen big. We carry on to parts of pancreases organization live the check discover the bureau of cooking stove lymphoid cell come together, considered duplicating of the HCV virus in the pancreas may cause the B cell function to crock up, thus caused the occurrence Of type 2 diabetes .At the same time, the HCV infection can cause the oneself immunity respond of the pancreas cell which caused the pancreas cell damage and the B cell function lower, thus resulted in the occurrence Of type 2 diabetes . Currently many researches express that insulin -resistant occupy the important position in the pathogenesis of type 2 diabetes. How HCV infection cause insulin–resistant still not explicit. HCV infection results in the liver cell steatosis and liver inside iron of content increment which caused insulin-resistant, and the insulin-resistant can affect the metabolism of iron and cause the fatty liver disease take place. Thus past their three existence crosses the function mutually. Recently many researches indicate that the patients with chronic HCV merger diabetes exist high serum insulin levels and the reaction of insulin descending, which considered its mechanism is the B cell function descending and insulin-resistant. There will be the B cell function descending in the...