Clinical Study On The Dynamic Changes Of Plasma D-dimer And Fibrinogen In Patients With Acute Cerebral Infarction

Background: Plasminogen activation and coagulation are main pathophysiological processes of thromboembolic disease. Acute cerebral infarction(ACI) refers to the tissue damage that results from intracranial artery thrombosis. More and more experts lay emphasis on whether there are some abnormalities in coagulative and fibrinolytic system in patients with acute cerebral infarction. The domestic and foreign clinical researches indicate that ischemic cerebrovascular disease correlate with disorders in coagulative and fibrinolytic system, but, there are different opinions that How about do plasminogen activation and coagulation change and clinical significance.Methods: We investigated plasma levels of fibrinogen(Fg) and D-dimer(DD) in 53 patients with different infarction size and severity of size within 24 hours of onset and compared these to 40 age-matched healthy controls.Results: These results suggest that: (i) the plasma contents of D-dimer and fibrinogen in patients with acute cerebral infarction were significantly higher than those in control group (P<0.01), and (ii) the levels of D-dimer and fibrinogen were significantly correlated with the infarction size and severity of size (P<0.05).(iii) Levels of the plasma D-dimer and fibrinogen in patients group with acute cerebral infarction were positive correlation(r= 0.486, P<0.01).