The Effects Of Intracranial Pressure On The Cerebral Venous Infarction In Rabbits

Objective To investigate the effects of intracranial pressure on the cerebral venous infarction in Rabbits,using the intravenous infarction model of Rabbits,in order to offer the new way and the experimental base for the treatment of intravenous infarction and high intracranial pressure in patients.Methods Ninety health Japanese Big-ear Rabbit (Lepus brachyurus) were randomly divided into seven groups.Group A:the group in which both the posterior 1/3 superior sagittal sinus and its reflux veins was ligated(n=18);Group B:the group in which both the posterior 1/3 superior sagittal sinus and its reflux veins was ligated with a 0.2ml epidural space balloon (n=18);Group C:the group in which both the posterior 1/3 superior sagittal sinus and its reflux veins was ligated with a 0.4ml epidural space balloon (n=18); Group D:the group in which both the posterior 1/3 superior sagittal sinus and its reflux veins was ligated with a 0.6ml epidural space balloon (n=18);Every group divide into three sub-groups according to the different time in the first four group.Every sub-group has 6 Rabbits in 8h,24h and 48h,named A8,A24,A48……D48.Group E:sham operation(n=6).Water content ratios of the brain and the range of cerebral venous hemorrhagic infarction were obtained at an interval of 8h,24h,48h,respectively after operation. Macroscopic examination,lightscopy ,the hemorheological parameters ,plasma D-dimer and fibrinogen was compared with these data.Group F:the group in which both the posterior 1/3 superior sagittal sinus and its reflux veins was ligated with a 0.6ml epidural space balloon and get out the ballon after 8h. Group G the group in which both the posterior 1/3 superior sagittal sinus its reflux veins was ligated and with a 0.6ml epidural space balloon and get out the ballon after 24h,Water content ratios of the brain and the range of cerebral venous hemorrhagic infarction were obtained at an interval of 48h after the operation. Results The contents of water in brain tissue of group D at 8h,24h,48h after operation were higher than those of group A and group E.The range of cerebral venous hemorrhagic infarction of group D at 8h,24h,48h after operation were higher than those of group A and group E,so as the hemorheological parameters (except plasma viscosity)and plasma fibrinogen levels.The contents of water in brain of group D were higher than those of group F and group G,so as the range of cerebral venous hemorrhagic infarction.With progressive increase of intracranial pressue,the contents of water in brain raised,so as the range of cerebral venous hemorrhagic infarction.the hemorheological parameters (except plasma viscosity)and plasma fibrinogen levels.Conclusion Intracranial hypertension can significantly increase the contents of water in brain and the range of cerebral venous hemorrhagic infarction in the model of cerebral venous infarction in Rabbits.Removal of intracranial hypertension can significantly reduce contents of water in brain and the range of cerebral venous hemorrhagic infarction in the model of cerebral venous infarction in Rabbits. With progressive increase of intracranial pressue, the hemorheological parameters (except plasma viscosity)and plasma fibrinogen levels raised.