Clinical Study Of Influence Of Cardiopulmonary Bypass On Coagulation Using Sonoclot Coagulation And Platelet Function Analyzer

Objective Cardiopulmonary bypass (CPB) would disturb coagulation. We investigated the influence of CPB on hemostatic system using Sonoclot (SCT) coagulation and platelet function analyzer and the routine coagulation tests (SCT), in order to find out the actual hemostatic status after CPB and analyze the mechanism of blood protection with aprotinin so to provide guidance for the clinicians in using blood products and hemostatics application. Methods 35 patients undergoing coronary artery bypass graft surgery (CABG) were randomly divided into Aprotinin group (n=20) and Control group (n=15). Aprotinin group received 2.5×10~6 KIU of aprotinin intravenously after incision and another 2.5×10~6 KIU in the priming fluid. CPB was accomplished with a STOCKERT-C roller pump(Germany), primed with crystalloid and colloid fluid, a dideco 703 membrane oxygenator was applied. Mild hypothermia and moderate-to-high flow were performed during CPB. Blood samples were collected from central vein pre-operation, pre- and post-CPB for determination of SCT (gbACT, Clot Rate, Platelet Function) and RCT (ACT, PT, APTT, Fbg, Hb, PLT, D-dimer). The amount of mediastinal drainage and blood transfusion after operation was recorded.Results 1.SCT results show: Pre-operation all SCT parameters were in normal range. Before CPB, gbACT prolonged markedly (P<0.01),CR and PF decreased(P<0.05) respectively in Aprotinin group. There were no changes in Control group(P>0.05). After CPB gbACT was significantly prolonged, CR and PF decreased significantly (P<0.01) in both groups. 2. RCT results show: Before...