The Effect Of Different Dose Of Aprotinin On Blood Coagulation Functions In Patients Undergoing Unilateral Total Hip Replacement

Objective: Aprotinin, a hemostaic agent, regulates fibrinolysis, modulates the intrinsic coagulation pathway, stabilizes platelet function, and exhibit antiinflammatory properties through inhibition of serine proteases.Aprotinin has been used successfully for many years in cardiacoperations, and there have been prelimmary investigations of its use in hip replacement operations.It was reported that aprotinin could decrease blood loss and percentage of transfusion in hip replacement operation,but there were no conclusions that the relationship between coagulation and dosage and whether it can increase the prevalence of DVT. The trial was to observe the effect of aprotinin on blood coagulation functions in patients undergoing a primary unilateral total hip replacement and to examine its effect on the prevalence of distal and proximal deep-vein thrombosis (DVT) of both legs with color Doppler imaging.Methods: 100 patients undergoing primary unilateral total hip replacement were chosen, randomly divided into four groups (35female and 55 male, weighing 55～75kg, aged 52～75years),ASAⅠorⅡ, with 25 in each group. A low dose of...