Hemorheologic Changes In Patients With Chronic Hepatitis B

Objectives:To study the variation of the hemorheology in patients with chronic hepatitis B and study the relations within HBVDNA , liver function, oxidative stress markers . It is to guide clinic work for the future and can extend in the clinic.Methods:The controls include 10 females and 10 males whose ages from 9 to 40. These selected normal persons have not any disease. The subjects were 55 patients with chronic hepatitis B, who include 43 males and 12 females, and who had been admitted to our hospital and accorded with diagnosis criterion publicized at 2000. These selected patients have not other diseases. Taking five milliunit empty stomach venous blood into a cuvette which has anticoagulant, then testing the example with R-80 type hemorheology apparatus. Testing other blood for liver function, HBV-DNA. By using computer to calculate and compare the indicators of hemorheology between hepatitis B group and control group. It is by chemic colorimetry that MDA, XOD and vitamin E are tested.Result:1. The rate of normal alanine aminotransferase(ALT) was49.09 % and the rate of abnormal ALT was 50.91 % in all 55 patients with chronic hepatitis B. The rate of positive HBV DNA was 76.36% and the rate of negative HBV DNA was 23.64% in all patients.2. The low-shear whole blood viscosity (BV), Hematocrit (HCT). Plasma viscosity , RBC aggregation index were significantly higher in chronic hepatitis B group than those in the control group (P<0.05 )3, Hematocrit (HCT), the low-shear BV, RBC aggregation index were significantly higher in the patients whose ALT is higher than the controls4, Hematocrit (HCT), the low-shear BV, RBC aggregation index were significantly higher in the patients whose ALT is normal than the controls5, No significant difference was found within HBVDNA and indices of hemorheology (P>0.05) .6, No significant difference was found within indices of hemorheology and oxidative stress markers (P >0.05) Conclusion:1, There are microcirculation disturbance and oxidative stress in the body of patients with chronic hepatitis B.2, The hemorheology should be a indicator in detecting hepatic diseases.3, The hemorheology , oxidative stress markers and HBVDNA are independently indicators in detecting hepatic diseases.