Patients With Chronic Hepatitis B Resistance To Oxidative Damage And Immune Regulation

Objective :This experiment mainly investigate changes of antioxidation ability in patients with chronic hepatitis B, through measuring xanthine oxidase and vitamin E in the serum. This experiment can guide clinical works for the future and can extend in the clinic.Methods:The controls include 5 females and 5 males whose ages from 26 to 49. These selected normal persons have not any disease. The subjects were 37 patients with chronic hepatitis B, who include 21 males and 16 females, and who had been admitted to our hospital and accorded with diagnosis criterion publicized at 2000. These selected patients have not other diseases. It is by chemic colorimetry that xanthine oxidase and vitamin E are testd.Result: 1. The rate of nomal alanine aminotransferase(ALT) was 51.35% and the rate of abnormal ALT was 48.65% in all 37 patients with hepatitis B.The rate of positive HBV DNA was 78.38% and the rate of negative HBV DNA was 21.62% in all patients. Genotype B was detected in 7 case(24.14%),genotype C was detected 12 in cases(41.38%),genotype D was detected in 6 cases(20.69%) and mixed genotypes in 4 cases( 13.79%) in all the positive HBV DNA.2. The concentration of xanthine oxidase of the patients B in serum is significantly higer than the concentration of the controls(P < 0.01).And the concentration of vitamin E of the patients B in serum is significantly lower than the...