Study Of Correlation Between Serum Adiponectin Level And Insulin Sensitivity In Patients With Type 2 Diabetes Mellitus

Objective: All through the 20th century, diabetes mellitus( DM ) has ranked the third with regard to health and social significance followed cardiovascular diseases and tumor. Insulin resistance is an important factor that influences the happening and progress of type 2 diabetes mellitus. In searching for the unknown causes of insulin resistance,special attention has been paid in recent years to adipocytokines. Adiponectin is one of the newly founded adipocytokines. The aim of this study was to explore the relationships among adiponectin, insulin resistance and obesity in a population with type 2 diabetes mellitus. Methods: Fasting serum adiponectin, blood glucose and insulin levels were determined in 58 type 2 diabetic patients and 20 healthy control subjects. Serum adiponectin was determined by colorimetric enzyme-linked immunosorbent assay. HOMA-IR was calculated by HOMA model. The correlation between serum adiponectin level and insulin sensitivity was analysised by SPSS10.0 software. Results: 1.The patients were assigned to three groups based on their body mass index (BMI):normal-weight group,overweight group and obesity group. Significant differences of BMI exist among these groups(P<0.01). 2. Serum adiponectin levels in three diabetic groups were lower than which in controls, those in overweight group and obesity group were significantly lower than in controls(P<0.01). HOMA-IR levels in three diabetic groups were significantly higher than which in controls(P<0.01). 3. There was a negative correlation between serum adiponectin levels and BMI in all studied subjects(r=—0.54,P<0.01). There was also a negative correlation between serum adiponectin levels and HOMA-IR in all studied subjects(r= —0.46,P<0.01). Conclusion: Serum adiponectin levels in a population with type 2 diabetes mellitus were lower than which in controls. There was a negative correlation between serum adiponectin levels and insulin sensitivity. The decrease of serum adiponectin levels perhaps plays an important role in the mechanism of insulin resistance.