The Diagnostic Value Of Plasma Of Natriuretic Peptides And The Influences Of Carvedilol On The Left Ventricular Function And Plasma Of Natriuretic Peptides In Patients With Chronic Heart Failure

Objective: To investigate the correlations between the left ventricular function and plasma levels of B-type natriuretic peptides (BNP) in patients with chronic heart failure (CHF). To investigate the correlations between the effects of carvediol on the left ventricular function and plasma levels of B-type natriuretic peptides (BNP) in patients with chronic heart failure(CHF).Methods: (1) BNP levels were measured by Enzyme-Linked Immunosorbent Assay(ELISA) in 56 CHF patients and 20 normal groups. Doppler echocardiography was performed to evaluate left ventricular function. (2) 32 CHF patients were randomly assigned to receive carvediol and conventional therapy for a total of 6 months. BNP levels and left ventricular function were measured by ELISA and echocardiography in these patients before and after treatmentResults: (1) The mean BNP concentration in the blood of patients with CHF was higher than it was in normal groups(408±78pg/ml vs 34.55±19. 62pg/ml, p<0.01).BNP correlated with LVEF (r= - 0.48). (2) 29 patients with CHF of New York Heart Association(NYHA) class Ⅱ or Ⅲ were studied, BNP levels were greater in the patients with chronic atrial fibrillation (AF) than those in the patients without AF (588.53±104.25 pg/ml vs445.69±139. 48pg/ml,p<0.05). (3) After 6 months optimized treatment, BNP levels decreased and LVEF was improved in both groups, whereas there was significant difference between carvedilol groups and conventional groups. BNP levels significantly dropped in patients with carvediol compared with inpatients with conventional treatment (485.78±56.41pg/ml vs 386.82±45. 36pg/ml, p<0.01). there was an increase of LVEF in patients with carvedilol compared with conventional treatment(43.38±8.25 vs 38.9±7.84, p<0.05)Conclusions: B-type natriuretic peptide (BNP) is a sensitive marker of ventricular dysfunction and its dosage is correlated with the severity of the dysfunction. BNP measurement is used in diagnose in CHF. Patients treated with carvedilol in addition to the conventional therapy for CHF show beneficial effects on left ventricular function. BNP levels obviously decreased in patients with carvediol groups.