The Comparison Between The Curative Effect Of Esmeprazole And Omeprazole In H.pylori-positive Acute Duodenal Ulcer44

Objective: Proton pump inhibitor (PPIs) -based triple therapy is recognized as the best therapeutics on the Helicobacter pylori. associated peptic ulcer. Esomeprazole is the newest PPIs. The purpose of this study was to compare the efficacy of esomeprazole or omeprazole at eradicating of H.pylori, the cicatrisation of ulcer and the control of clinical symptoms. Methods: A total of 60 H.pylori-positive patients with acute duodenal ulcer received twice daily treatment with esomeprazole (E) 20 mg (n=30) or omeprazole (O) 20 mg (n=30) in combination with amoxicillin (A) 1 g and clarithromycin (C) 500 mg for 1 week . After completion of therapy 4 weeks later, we compared the ulcer healing, Hp status and the clinical symptoms between two groups. Ulcer healing was assessed by endoscopy, and Hp status was assessed by ~14C-ure breath testings. The control of clinical symptoms was assessed by clinical symptoms classification. Results: The Hp eradication rates (95%CI) were: EAC 90% (73%~98%); OAC 80% (61%~92%).The ulcer healing rates were:EAC 86.7%; OAC 80%.The esomeprazole-based triple therapy can better control clinical symptoms (upper abdomen pain, heartburn, acid reflux) than omeprazole- based triple therapy,and the data has statistical correlation. Conclusions: A 1-week esomeprazole-based triple therapy has same effect with omeprazole-based triple therapy for ulcer healing and Hp eradication in patients with DU disease, and esomeprazole-based triple therapy has a more efficacy for clinical symptoms (upper abdomen pain, heartburn, acid reflux ) control.