| Objective: The treatment of infertility by in vitro fertilization and embryo transfer(IVF-ET) is widely used in the clinic for the age of women who want to pregnant is becoming older and the infertility rates is becoming higher .Therefore more and more scholars have paid attention into the problem that how to predict the IVF-ET outcomes. Several factors may influence the outcomes from IVF. Generally speaking that retrieving enough maturate oocyte in the superstimulation ovulation treatment was the key to the success of the IVF .As a result, ovarian reserve function had played an important part in the IVF. The basal serum FSH, inhibinB were indexes to reflect the ovarian reserve function. However, the clinical predictive value of the basal serum hormone levels to the IVF outcome has still been disputed by many scholars. Leptin,a peptide hormone encoded by the obesity gene, correlate strongly with parameters of body adiposity, such as body mass index(BMI), the relationship between leptin and human reproductive function has been concerned by people in recent years for a wealth of recent studies have indicated the impact of leptin in assisted reproduction cycles. The objective of the present study was to determine whether IVF outcomes (e.g. fertilization, implantation, and pregnancy) correlate with the basal serum FSH, inhibinB, leptin/BMI.Methods: A one hundred and eighty IVF cycles-technique was carried out in one hundred and twenty-nine infertile women in our center from September 2003 to May 2004.The day two fasting serum FSH, inhibinB, leptin of the infertile women were measured. All of the women received the standard controlled superstimulation ovulation treatment and the clinical data of IVF were registered .The age, poor ovarian response rates, cycle cancelled rates, number of mature oocytes retrieved per cycle, fertilization rates, cleavage rates, number of embryo transfer per cycle, implantation rates, pregnancy rates were investigated and compared in different FSH levels groups, different inhibinB levels groups and different leptin/BMI levels groups.Results: Our studies indicated that with the increase of the serum FSH levels, the ovarian response decreased (P<0.01), however, the pregnancy rates decreased significantly only when FSH>10IU/L (P<0.05). Comparing the IVF indexes between the age≥35years; FSH<10IU/L group and the age<35years; FSH≥10IU/L group, the ovarian response was higher in the former group (P<0.01), however the pregnancy rate did not differ between the two groups (P>0.05) for the former group with lower implantation rate (P>0.05). The ovarian response increased with the increase of theserum inhibinB levels ,the inhibinB ^ 50pg/ml predicted a poor IVF outcome (P<0.05).The age^35years; inhibinB>50pg/ml group was with higher ovarian response than the age<35years;inhibinB^50pg/ml group, but the pregnancy rates were similar between two groups (P>0.05). There was significantly difference of number of mature oocytes retrieved per cycle in different leptin/BMI levels groups (P>0.05), the leptin/BMI>0.60 predicted significantly decreased pregnancy rates (P<0.05).Conclusion: The results of this research showed that basal FSH was a good index to assess the ovarian response, but the predict value for pregnancy in clinic is limited. Basal inhibinB can better reflect the ovarian response, and superior to FSH for predicting pregnancy, but still can not isolated with age. Leptin/BMI also can predict the IVF-ET outcome, and the sensitivity is higher, but the predict value for the ovarian response is poor. |
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