The Effects Of Modified Citrus Pectin On Blood Glucose In Mice With Diabetes Mellitus

Objective:To study the effects of modified citrus pectin on blood glucose in mice with diabetes mellitus.Methods:300ICR mice (25.12 ± 1.27 g) were divided into 5 groups randomly. These mice were all female. The control group (group A) was fed on normal diet. Group A had 30 mice. The other 270 mice were injected in 2% alloxan and fed on normal diet. Choose the value of blood glucose between 15³0 mmol/L as the model sample. After the formation of diabetes model, these 88 mice were divided into 4 groups according to their value of blood glucose and body weight. Group A and B were i.g. distilled water, group C, D and E were i.g. 800 mg.kg^-1.d^-1 MCP, 1600 mg.kg^-1d^-1 MCP and 2400 mgkg^-1.d^-1 MCP respectively. The duration was 6 weeks. The effects of MCP on metabolism of glucose and pancreas of these mice were observed.Results:1. Compared group A with the other four groups respectively, the difference was significant (P<0.001). It showed that the diabetes model was successful.2. I.g. MCP for 6 W, compared group A with the other four groups respectively, thedifference was significant;compared group B with group C and D respectively, the difference was significant. It showed that MCP had the effect of decreasing fasting blood glucose.3. Effects on pancreas tissue: the pancreas of group A mice were normal, and group B were damaged at different level. The majority pancreas of group CU D and E were normal, but the quantity of pancreas was less than group A.Conclusions:1. MCP can decrease the blood glucose.2. MCP can improve the condition of pancreas of these mice with diabetes mellitus.