Effects Of The α-Linolenic Acid Of Silkworm Chrysalis Oil And Modified Citrus Pectin On Serum Lipids In Obese Rats

Hyperlipidemia can result in atherosclerosis and induce acute pancreatitis, it is also an important risk factor to the Complications of diabetes Mellitus. Currently the most commonly used lipid-regulating agents are statins, so lipid-lowering drugs are promising. Now the most studies of alpha-Linolenic acid are limited in perilla oil and flaxseed oil, and pupa oil are seldom studied, we observe the effects of the α-Linolenic acid of Silkworm Chrysalis Oil and MCP on lipid metabolism and the pathological changes in liver, kidney,pancreas and heart tissues in obese rats. and it can provide experimental evidence for further clinical application.Objective:to study the effort of the α-Linolenic acid of Silkworm Chrysalis Oil and MCP on lipid metabolism and the pathological changes in liver, kidney,pancreas and heart tissues in obese rats.Methods:90 normal SD rats whose weight was between 180g and 220g were divided randomly into six groups: model control group , 5-fold α-Linolenic acid fed group at the dose of 150mg/kg.d, 10-fold α-Linolenic acid fed group at the dose of 300mg/kg.d, 20-fold α-Linolenic acid fed group at thedose of 600mg/kg.d, 30-fold α-Linolenic acid fed group at the dose of 900mg/kg.d and MCP fed group at the dose of 800mg/kg.d. Body weight of rats, blood total cholesterol (TO , triglyceride (TG) , low - density lipoprotein - cholesterol (LDL - C) , high - density lipoprotein - cholesterol (HDL - C) levels were measured and the pathological changes in liver, kidney,pancreas and heart tissues were observed.Results:After fed with the α-Linolenic acid of the Silkworm Chrysalis Oil and MCP , The level of TC of the experimental rats were decreased in the rats of 600mg/kg.d, 900mg/kg.d and MCP groups, compared with model group, it had significant difference (P ＜0. 05) . The level of LDL - C of the experimental rats were decreased in the rats of 600mg/kg.d, 900mg/kg.d groups,compared with model group, it had significant difference(P(?)0. 05, P(?)0. 01(?)).Conclusion:The results suggest that α-Linolenic acid of the Silkworm Chrysalis Oil and modified citrus pectin (MCP) can decrease serum lipid in obese rats.