| Objectives: To investigate the correlation between coronary artery disease and chronic kidney disease, examine the relationship of renal damage with different degrees and prognosis of coronary artery disease. Methods: A retrospective study was performed in 733 patients who had been treated in our Cardiovasology Department and Cardiothoracic Surgery Department in 2000-2004. All patients suspected of coronary artery disease underwent a selective coronary angiography. Patients with established diagnosis of coronary artery disease were followed up and cardiovascular events were recorded. Chi-square test, CMH test and Logistic regression were used in the statistic analysis. Results: Chronic kidney disease was an independent risk factor for coronary artery disease. There was significant correlation between the severity of the coronary artery stenosis and levels of renal insufficiency, the severer the renal function damaged, the higher incidence of cardiovascular events. In patients with ACS, the higher levels of BUN, the higher incidence of angina pectoris, recurrent myocardial infarction and heart failure. Metabolic syndrome was significantly correlated with chronic kidney disease. Conclusions: Chronic kidney disease was an independent risk factor for coronary artery disease and the severity of chronic renal insufficiency was correlated significantly to the prognosis in coronary artery disease. In patients with ACS, the higher levels of BUN, the poorer the prognosis. Metabolic syndrome was significantly correlated with coronary artery disease and chronic kidney disease.
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