Expression And Clinicopathological Significance Of Several Kinds Of Multidrug-resistant Related Factors In Lung Carcinoma

objects and methods: We have investigated the protein and mRNA expression of multidrug-resistance related factors (multidrug resistance gene 1/P-glycorprotein, multidrug resistance-associated protein, lung resistance-related protein, p53 protein, c-erbB-2 protein and breast cancer resistance protein) in untreated lung cancer and corresponding normal lung tissues of adjacent tumor by means of immunohistochemistry and semi-quantitative reverse-transcription polymerase chain reaction.Result: The expressions of some of these factors elevate in tumor tissue, and correlated with the clinicopathologic parameters (such as the pathologic type, the degrees of differentiation, the status of metastasis of lymph node ) and the prognosis, and have relationship with eath other. Conclusion: It indicated that these factors may play some roles in the intrinsic multidrug resistance of lung cancer (major in the non-small cell carcinoma) in some extent, and may correlate with each other in the formation of MDR. It was significance for combining detection of the expression levels of these drug-related factors in lung career patients that in the prediction of the intrinsic multidrug resistance and in the guidance to rational chemical therapy.