The Clinical Prognostic Analysis Of 64 Epithelial Ovarian Cancer

Objective: To investigate the influence of different age, clinical stage, pathological grade, pathological types, side of the residue, courses of chemotheraphy, and edema condition on the prognosis of epithelial ovarian carcinoma. Methods: The clinical data and follow-up data of 64 epithelial ovarian carcinoma patients who were treated in our hospital from February 1995 to February 2005 were retrospectively studied. The Kaplan-Meier method, log-rank test and the COX proportional hazards regression model were used to identify prognostic factors. Results: The median survival of 64 patients with epithelial ovarian carcinoma was 26 months. The survival rate of patients in early stage (FIGO stage Ⅰ and Ⅱ) is significantly higher than of patients in advanced stage (FIGO stage Ⅲ and greater) (p<0.01). All patients received surgical therapy. Among advanced stage of patients, good cytoreductive surgery (no residue or residue < 2cm) was performed to 20 patients and their survival rate was significantly higher than these of 18 unsuccessful cases (residue≥ 2cm), 26 patients undertook 6 or more courses of chemotherapy their survival rate also significantly higher than of 38 patients who undertook less than 6 courses. The survival rate of patients with different pathological grade has significant differences (p < 0.05). But prognosis could not be significantly influenced by age, pathological types, chemotherapy intervals and edema conditions (P>0.05). Clinical stage, size of residue and the courses of chemotherapy were proved to be independent prognostic factors by COX proportional hazards regression model. Conclusion: Early diagnosis, primary optimal cytoreductive surgery and 6 or more courses of chemotherapy might improve the survival of patients with epithelial ovarian carcinoma.