The Study For The Relationship Between C-664G Polymorphism Of Human Atrial Natriuretic Peptide Gene And The Hypertension In Xinjiang Kazakans

Objective: To investigate the relationship between the C-664G allele polymorphism of human atrial natriuretic peptide (hANP) gene and essential hypertension in Kazakans of Xinjiang. Methods: Polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) methods were used to detect the C-664G polymorphism of hANP gene in Kazakans including 260 patients with essential hypertension (EH) and 169 normotensiye group(NT). Results: (l)The genotype frequencies of C-664G were CC 0.99 CG 0.01 in EH and 0.99 0.01 in NT respectively; The C-664and G-664 allele frequencies were 0.99 0.01 in EH and 0.997 0.003 in NT respectively; The hANP genotype distribution and the allele frequencies of C-664and G-664 were not statistic significances in EH compared with NT (P>0.05). (2)There were 4 patients with CG genotype and all of them were female . The CG genotype frequencies and G-664 allele frequencies in female EH were higher than that in female NT (P> 0.05). Conclusion: (l)There was no significant association found between the C-664G polymorphism of hANP gene and essential hypertension in Kazakans of Xinjiang. (2) the C-664G polymorphism of hANP gene might be associated with gender in Kazakans of Xinjiang...