Cerebral Arteriovenous Malformations: The Relationship Between Clinical Related Events And Regional Cerebral Blood Flow Imaging Of Single-photon Emission Computed Tomography

Object To evaluate the relationship between clinical related events and the regional cerebral blood flow (rCFB) imaging of single-photon emission computed tomography (SPECT) in patient with cerebral arteriovenous malformations.Methods 1.16 cases with AVM were examined routinely by SPECT before and after treatment. And the rCFB at different regions of interesting were compared with clinical related events. 2. The rCFB were measured in 18 AVM cases and compared with hemorrhage history.3. The rCFB SPECT image of brain with AVM, cavernous malformations, carotid cavernous f istulous, scar after AVM resection, hematoma, gliomas and brain of normal people were compared .Result 1. Before therapy, the mean rCBF in cerebral tissue adjacent to AVMs of hypoperfusion interpreted as cerebrovascular steal was 0.949 ± 0.014. After therapy, it was 0.995 ± 0.016 (P<0. 001). One patient developed ischemia and two patient developed early normal perfusion pressure breakthrough(NPPB) was diagnosised by SPECT after therapy. 2. The hemorrhage proportion of rCBF reduction less than 0. 75 was 3/11. Contrarily, it was 8/11 (Fisher probabilities in 2×2 table, P=0. 025) 3. The rCFB SPECT image of AVM pointed out hypoperfusion in more extensive regions than the defects shown by DSA, CT, MRI.Conclusion 1.The rCBF in cerebral tissue adjacent to AVMs showed mostly improvement after therapy in the study. And SPECT offers objective criterion for differentiating between ischemia and hyperperfusion. 2. AVM with rCBF reduction more than 0. 75 in the rCBF SPECT imaging inclines to hemorrhage.3. Cerebral tissue adjacent to AVMs showing cerebrovascular steal is AVMs' feature in rCBF SPECT imaging. So SPECT have a high diagnostic value in evaluation of cerebral arteriovenous malformations. It will be warranted widespread use in clinical practice.