| Objective: The paper purposed to investigate the therapeutic effect and mechanism of hypertonic sodium chloride hydroxyethyl starch-40 injection(HSH)on cryogenic brain injury. Methods: The paper established and deployed cryogenic brain injury rats model to study the therapeutic action and the dose-effect relation of HSH, so as to explore the optimal dose to treat brain edema. Results: HSH could decrease intracranial pressure (ICP) post cryogenic brain injury and keep the ICP at a lower lever. Different dosage of HSH has different acting time respectively on keeping the ICP. Conclusion: HSH has the therapeutic effect on cryogenic brain edema in rats. An ideal dose to treat brain edema has been observed successfully for HSH. |
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