| Objective: In order to demonstrate the value of cardiovascular risk factors, this research is to discuss the relationship between the level of blood lipid and characteristics of injured coronary artery, and the relationship between NHDL-C, Log(TG/HDL),LP(a)/HDL which may be risk factors for coronary heart disease and injured coronary artery further for prevention and treatment of coronary heart disease.Methods: By retrospective case analysis, we studied 407 cases admitted in cardiology department and operated on coronary angiography from Feb. 1.2005 to Feb. 10.2006. The severity of coronary artery stenosis was measured though angiography image system. Coronary stenosis ≥50% enrolled in coronary artery disease group. No stenosis in control group, and the severity of lesion was graded. According to the luminar diameter of coronary artery, 50%-69%, 70%-89%, 90%-100% were defined as low-grade, middle-grade, high-grade stenosis respectively. According to the number of suffered coronary artery, single branch, double branches and several branches were defined. Patients' preprandial blood was examed by routine assay.Compute NHDL-C, Log(TG/HDL) and LP(a)/HDL.Results:1. TC and coronary pathological change The concentration of TC in coronary artery disease group is higher than in control group(P<0.05). The concentration of TC in high-grade is higher than in low-grade (P<0.05). The concentration of TC in several branch group is higher than in single branch group (P<0.05). It indicates by Spearman's correlation analysis a positive correlation was found between coronary pathological grade(integral) and TC (r=0.236, P=0.000;r=0.181, P=0.004).2. TG and coronary pathological change The concentration of TG in coronary artery disease group is higher than in control group(P<0.01). The concentration of TG decreases gradually, but has no significant difference. It indicates by Spearman's correlation analysis a positive correlation was found between coronary pathological grade(integral) and TG (r=0.181, P=0.004;r=0.157, P=0.017).3. LDL and coronary pathological change The concentration of LDL in coronary artery disease group is higher than in control group(PO.OOl). The concentration of LDL in high-grade is higher than in low-grade (PO.05). It indicates by Spearman's correlation analysis a positive correlation was found between coronary pathological grade and LDL (r=0.132, P=0.038).4. HDL and coronary pathological change The concentration of HDL in coronary artery disease group is lower than in control group(P<0.001). The concentration of HDL in high-grade is lower than in low-grade (PO.05). The concentration of HDL in middle-grade is lower than in low-grade (P<0.05). The concentration of HDL in several branch group is lower than in single branch group and in double branch group (PO.01). It indicates by Spearman's correlation analysis a negative correlation was found between coronary pathological grade(range) and HDL (r=-0.195, P=0.038;r=-0.234, PO.001).5. apoA-I and coronary pathological change The concentration of apoA-I in coronary artery disease group is lower than in control group(P<0.001). The concentration of apoA-I in high-grade is lower than in low-grade (P<0.01). The concentration of apoA-I in several branch group is lower than in single branch group and in double branch group (PO.001). It indicates by Spearman's correlation analysis a negative correlation was found between coronary pathological range and apoA-I (r=-0.323, PO.001).6. apoB and coronary pathological change The concentration of apoB in coronary artery disease group is higher than in control group(P<0.001).The concentration of apoB in high-grade is higher than in low-grade (PO.05). It indicates by Spearman's correlation analysis a positive correlation was found between coronary pathological grade and apoB (r=0.137, P=0.031).7. LP(a) and coronary pathological change The concentration of LP(a) in coronary artery disease group is lower than in control group(P<0.001). The concentration of LP(a) in high-grade is higher than in low-grade (P<0.001). The concentration of LP(a) in middle-grade is higher than in low-grade (P<0.001). It indicates by Spearman's correlation analysis a positive correlation was found between coronary pathological grade(range, integral) and LP(a) (r=0.318, PO.001;r=0.254, PO.001;i=0.252, P O.001).8. Log(TG/HDL) and coronary pathological change The concentration of Log(TG/HDL) in coronary artery disease group is higher than in control group(P<0.001). The concentration of Log(TG/HDL) in high-grade is higher than in low-grade and middle-grade (P<0.001). The concentration of Log(TG/HDL) in several branch group is higher than in single and double branch group (P<0.001). It indicates by Spearman's correlation analysis a positive correlation was found between coronary pathological grade(range, integral) and Log(TG/HDL) (r=0.238, PO.001;r=0.282, P=0.003;i=0.216, P =0.003).9. NHDL-C and coronary pathological change The concentration of NHDL-C in coronary artery disease group is higher than in control group(PO.Ol). The concentration of NHDL-C in high-grade is higher than in low-grade and middle-grade (PO.001). The concentration of NHDL-C in middle -grade is higher than in low-grade (P<0.05).The concentration of NHDL-C in several branch group is higherthan in single branch group (P<0.01). The concentration of NHDL-C in double branch group is higher than in single branch group (PO.05). It indicates by Spearman's correlation analysis a positive correlation was found between coronary pathological grade(range, integral) and NHDL-C (r=0.290, PO.001;r=0.191, P=0.003;r=0.223, P O.001).10. LP(a)/HDL and coronary pathological change The concentration of LP(a)/HDL in coronary artery disease group is higher than in control group(PO.Ol). The concentration of LP(a)/HDL in high-grade is higher than in low-grade and middle-grade (P<0.001). The concentration of LP(a)/HDL in middle -grade is higher than in low-grade (P<0.05).The concentration of LP(a)/HDL in several branch group is higher than in single branch group (PO.01). The concentration of NHDL-C in double branch group is higher than in single branch group (P<0.05). It indicates by Spearman's correlation analysis a positive correlation was found between coronary pathological grade(range, integral) and LP(a)/HDL (r=0.477, P<0.001;r=0.446, P=0.003;r=0.332, P <0.001). The abnormality rate was significantly higher than NHDL-C and Log(TG/HDL). Conclusions:1. Serum TC> TG> LDL-C> LP(a)^ apoB are risk factors for coronary artery disease. HDL-C> apoA-I are protecting factors.2. A positive correlation between coronary pathological grade(range, integral) and the level of serum NHDL-C, Log(TG/HDL) were found, and they are risk factors for coronary artery disease.3. A positive correlation between coronary pathological grade(range, integral) and the level of serum LP(a)/HDL were found and the abnormality rate was significantly higher than NHDL-C and Log (TG/HDL). It is an important risk factor for coronaryartery disease.
|
PDF Full Text Request